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The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease

  • John E. Lewis, Steven E. Atlas, Oscar L. Higuera, Andrea Fiallo, Ammar Rasul, Ashar Farooqi, Olga Kromo, Laura A. Lantigua, Eduard Tiozzo, Judi M. Woolger, Sharon Goldberg, Armando Mendez, Allan E. Rodriguez, and Janet Konefal
  • 2018

Te primary objective of the study was to evaluate the efect of a hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), on biomarkers in adults with nonalcoholic fatty liver disease (NAFLD). A 90-day randomized double-blind placebocontrolled trial examined the efect of RBAC on complete blood count, liver enzymes, lipids, oxidative stress markers, cytokines, and growth factors. Twenty-three adults with NAFLD were enrolled and randomly assigned to one of the two study conditions (n = 12 RBAC and n = 11 placebo) and consumed 1 gram/day of either compound for 90 days. Subjects were assessed at baseline and 45 and 90 days. No adverse efects were reported. Alkaline phosphatase signifcantly decreased (−3.1%; SD = 19.9; F[1, 19] = 5.1, p = 0.03) in the RBAC group compared to placebo. Percent monocytes (17.9%; SD = 18.3; F[1, 19] = 5.9, p = 0.02) and percent eosinophils (30.6%; SD = 30.5; F[1, 19] = 12.3, p < 0.01) increased in the RBAC group. IFN-gamma (156%; SD = 131.8; F[1, 19] = 4.2, p = 0.06) and IL-18 (29.1%; SD = 64; F[1, 19] = 5.3, p = 0.03) increased in the RBAC group compared to placebo. Other improvements were noted for platelets, neutrophils, neutrophil-lymphocyte ratio, gamma-glutamyl transferase, and 4-hydroxynonenal. RBAC had benefcial efects on several biomarkers that add to the known immunomodulatory activities of RBAC, which may be promising for people with NAFLD.

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