Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D -Galactosamine-Induced IL-18 Expression and Hepatitis in Rats
- Surina Z HENG, Hiroo S ANADA, Hirofumi D OHI, Shizuka H IRAI, and Yukari E GASHIRA
We investigated in this study the effect of modified arabinoxylan from rice bran (MGN-3) and its fractions on D -galactosamine ( D -GalN)-induced IL-18 expression and hepatitis in rats. Male Wistar rats were pretreated with MGN-3 or fractions of the MGN-3 hydrolysate, or with saline 1 h before administering D -GalN (400 mg/kgB.W.). The serum transaminase activities, IL-18 mRNA expression level in the liver and IL-18 concentration in the serum were determined 24 h after injecting D -GalN. Both the oral and intraperitoneal administration of MGN-3 (20 mg/kg B.W.) alleviated D -GalN-induced hepatic injury under these experimental conditions. The low-molecular-weight fraction (LMW) of MGN-3 showed the strongest protective effect on D -GalN- induced liver injury, its main sugar component being glucose. Moreover, the D -GalN-induced IL-18 expres- sion was significantly reduced by treating with MGN-3 and LMW. The results suggest that MGN-3 and LMW could provide significant protection against D -GalN liver injury, and that IL-18 might be involved in their protective influence.
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