Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin
- Yuzo Endo, Hiroshi Kanbayashi
Alkylating agents and antimetabolites remain prominent in a wide variety of cancer chemotherapy protocols on the basis of more selective effects on the faster than normal mitotic cycles of malignant cells. Among new platinum‐containing anticancer molecules, the lead compound cisplatin (Cis‐platinum (II) diammine dichloride) has been known to possess beneficial anticancer properties in terms of specific interaction of cisplatin and DNA strands. Cisplatin () has been encouraged for treatment of head and neck, bladder, and cervical cancers (), as well as breast cancer (). Although the prevalent incidence of lung, gastric, breast, colorectal and prostate cancers place them in top ranks of the most common cancers in the civilized countries, many of these advanced cancers are unresponsive to chemotherapy. Platinum‐based drugs would be a potent choice in these situations, but they frequently cause substantial side effects, such as nausea, vomiting, nephropathy and hypomagnesaemia due to damage of renal tubules (). Furthermore, in addition to hearing loss and peripheral neuropathy, myelosuppression is one of the most devastating suppressive side‐effects () leading to immunocompromized states. Therefore, any reduction of the side effects of cisplatin would be valuable. Thus, we explored the effect of modified rice bran on protection of weight loss of mice under tolerable maximal doses of cisplatin. Others have briefly commented on the antistress and antifatigue effects of fermented rice bran () or some beneficial effect of modified rice bran on some adverse actions of anticancer drugs in rats ().
What are cookies?
Cookies are small text files which can be sent to browser when you visit websites and saved to your device (computer or other device with Internet access, i.e. smartphone or tablet). Cookies are saved in the folder for files of your browser. Cookies usually contain the name of the website they come from and the date of origin. Upon your next visit the browser loads cookies again and sends these information back to the website which originally created cookies. Cookies we use do not harm your computer.
By using this website you give your consent to using cookies in compliance with your browser settings. If you visit our websites, acceptance of cookies is allowed in your browser, you do not change your browser settings and continue visiting our websites we consider it as accepting our conditions for using cookies.
Why are we using cookies?
Cookies are used to optimally create and constantly improve the quality of our services, adjust them to your interests and needs and improve their structure and contents. We do not use data obtained by using cookies to contact users by mail, e-mail or telephone.
How to change settings of cookies?
Majority of browsers have been originally set to automatically accept cookies. This settings can be changed by blocking cookies or by a notification in case cookies are to be sent to your device. Instructions for changing cookies are available in the option “Help” of every browser. If you use different devices to access websites (e.g. computer, smartphone, tablet), we recommend you to adjust every browser on each of them to your preferences regarding cookies.
Why to keep settings of cookies?
Using cookies and permitting cookies in your browser is your decision. However, in case you change settings of cookies, functionality of some of our websites can be limited and their user comfort reduced.