The basic study of arabinoxylan compound (MGN-3) on the activation of vital defence

Authors: N. Sudo, K. Tatoe, N. Koyama, H. Kanna, K. Hirayama, and C. Kubo

Abstract: Arabinoxylan (hereafter called MGN-3) is a plant polysaccharide processed food with a biophylactic action, which mainly contains polysaccharides such as hemicellulose and arabinoxylan and glycoprotein. MGN-3 is known to have various biophylactic actions such as in vitro NK cell activity stimulation and anti-HIV effect. In the present study, the vital defense activating effect of MGN-3 was studied in 3 animal experiments: Experiment 1 examined its effect on the survival in a lipopolysaccharide-induced lethal sepsis model, Experiment 2 studied the anti-stress effect on restraint stress, and Experiment 3 examined its effect on the survival of autoimmune disease-prone (NZB x NZW) F1 mice.